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She is the daughter of Greek-born actor John Aniston and American actress Nancy Dow.
Aniston gained worldwide recognition for portraying Rachel Green on the television sitcom Friends (1994–2004), a role which earned her a Primetime Emmy Award, a Golden Globe Award, and a Screen Actors Guild Award.
Following a four-year hiatus from cinema, Aniston returned to film work in 1996, when she performed in the ensemble cast of the independent films She's the One (1996), and Dream for an Insomniac (1998).In 2008, she co-founded the production company Echo Films.In 2012, Aniston received a star on the Hollywood Walk of Fame.The character was widely popular during the airing of the series and was later recognized as one of the 100 greatest female characters in United States television.Aniston has played the female protagonist in a number of comedies and romantic comedies.
Aniston's first starring vehicle was the film Picture Perfect (1997), in which she starred opposite Kevin Bacon and Jay Mohr.